OBJECTIVE: To evaluate the utility of conventional ultrasound and shear wave elastography in diagnosing papillary thyroid carcinoma with braf mutation. METHODS: A group of 73 malignant nodules getting BRAF mutation test results were enrolled in our research. We performed grey-scale ultrasound and 2D-SWE examinations before operation. All the nodules were divided into two groups according to the genetic tests. We used statistical software to investigate different parameters between two groups. RESULTS: BRAF mutation were found in 91.8%(67/73) thyroid papillary carcinoma nodules. Parameters of grey-scale sonography between two groups were not statistically significant. SWE measurements were significantly different between two categories. The maximum Young''s modulus value with positive results was 82.3±43.5kPa, as compared with 42.1±15.6kPa in negative results (p<0.05). On ROC curve, the area under the curve (AUC) of the maximum Young''s modulus value was 0.858. Taking 40.8kPa as the threshold of maximum Young''s modulus value, the sensitivity was 92.5% and specificity was 66.7%. CONCLUSIONS: The maximum Young''s modulus value of PTC nodules is correlated with BRAF genetic testing results.