摘要: |
目的 探究超声剪切波弹性成像(SWE)联合血清中期因子(MK)、胸苷激酶1(TK1)、促甲状腺素与甲状腺球蛋白(TSH/Tg)比值对甲状腺结节良恶性的鉴别诊断价值。方法 回顾性选取2020年5月到2022年5月期间我院收治的129例甲状腺结节患者(129枚结节)的临床资料,根据术后病理结果或穿刺结果分为良性组98例和恶性组31例,均行超声SWE检查及血清MK、TK1、TSH、Tg检测,比较两组SWE参数[最小弹性模量(Emin)、最大弹性模量(Emax)、平均弹性模量(Emean)],比较两组血清MK、TK1、TSH/Tg比值,通过受试者工作特征(ROC)曲线分析SWE参数联合血清MK、TK1、TSH/Tg比值对甲状腺结节良恶性的鉴别诊断价值。结果 与良性组比较,恶性组患者Emax、Emin、Emean值及血清MK、TK1、TSH/Tg比值均明显升高(P<0.05)。 SWE参数联合血清MK、TK1、TSH/Tg比值的曲线下面积(AUC)、灵敏度、特异度依次为0.893、83.92%、89.82%,其鉴别诊断甲状腺结节良恶性的价值显著优于各项指标单独使用。结论 SWE参数Emax、Emin、Emean值及血清MK、TK1、TSH/Tg比值在不同性质的甲状腺结节中存在明显差异,其联合检测对于鉴别诊断甲状腺结节良恶性具有较高的价值,相较各项指标单一应用而言更具优势。 |
关键词: 超声剪切波弹性成像 中期因子 胸苷激酶1 促甲状腺素与甲状腺球蛋白比值 甲状腺结节 良恶性 鉴别诊断 |
DOI: |
投稿时间:2022-12-02修订日期:2023-01-09 |
基金项目:湖北省卫生计生委联合基金立项项目(编号:WJ2018H0510) |
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The value of ultrasonic shear wave elastography combined with serum midkine, thymidine kinase 1, thyrotropin and thyroglobulin ratio in differential diagnosis of benign and malignant thyroid nodules |
Ke Shu-li |
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Abstract: |
Objective To investigate the value of ultrasonic shear wave elastography (SWE) combined with serum midkine (MK), thymidine kinase 1 (TK1), and the thyrotropin and thyroglobulin (TSH/Tg) ratio in the differential diagnosis of benign and malignant thyroid nodules. Methods The clinical data of 129 patients with thyroid nodules (129 nodules) who were admitted to our hospital from May 2020 to May 2022 were retrospectively selected. According to postoperative pathological results or puncture results, they were divided into benign group with 98 cases and malignant group with 31 cases, all of which underwent ultrasonic SWE examination and serum MK, TK1, TSH and Tg detection. SWE parameters [minimum modulus of elasticity (Emin), maximum modulus of elasticity (Emax) and average modulus of elasticity (Emean)] in the two groups were compared, and the serum MK, TK1 and TSH/Tg ratio in the two groups were compared. Receiver operating characteristic (ROC) curve was used to analyze the differential diagnosis value of SWE parameters combined with serum MK, TK1 and TSH/Tg ratio for benign and malignant thyroid nodules. Results Compared with the benign group, the Emax, Emin and Emean value and the serum MK, TK1 and TSH/Tg ratio in the malignant group were significantly increased (P<0.05). The area under curve (AUC), sensitivity and specificity of SWE parameter combined with serum MK, TK1 and TSH/Tg ratio were 0.893, 83.92% and 89.82%, respectively. The value of SWE parameter in the differential diagnosis of benign and malignant thyroid nodules was significantly better than that of each indicator alone. Conclusion The SWE parameters Emax, Emin, Emean values and serum MK, TK1, TSH/Tg ratio are significantly different in thyroid nodules of different properties. Their combined detection is of high value in the differential diagnosis of benign and malignant thyroid nodules, which is more advantageous than the single application of various indicators. |
Key words: Ultrasonic shear wave elastography Midkine Thymidine kinase 1 Thyrotropin to thyroglobulin ratio Thyroid nodules Benign and malignant Differential diagnostic |