摘要: |
目的 比较肝脏局灶性病变(FLLs)患者的灰阶超声影像组学和超声造影的诊断价值。方法 回顾性分析本院2017年2月-2021年11月诊治的162例FLLs患者临床资料,均在本院接受超声造影以及灰阶超声检查。比较两种检查方法对于FLLs的诊断价值。结果 恶性病灶超声造影特征:表现为肝动脉期病灶造影强度强于周围肝组织,门脉期病灶相比于周围肝组织呈低增强,且两者之间存在明显的分界;良性病灶超声造影特征:与周围肝组织比较,肝动脉期病灶呈等增强或稍高增强,造影剂从病灶周边缓慢向中心灌注,门脉期以及延迟期病灶内造影呈等增强或高增强,未见明显的造影剂消退现象。162例患者274个影像组学特征,以1个直方图特征、1个纹理特征以及3个小波特征作为预测因子;训练队列影像组学预测恶性病灶模型ROC曲线的曲线下面积(AUC)、敏感度、特异度分别为0.872、83.33%、80.00%,训练队列与验证队列的AUC值、敏感度、特异度比较无统计意义(P>0.05);验证队列分别为0.812、76.67%、79.24%;影像组学模型鉴别诊断的AUC值、敏感度以及特异度均显著高于超声造影(P<0.05)。结论 灰阶超声影像组学特征可有效诊断FLLs的良恶性,其诊断效能高于超声造影,可为临床诊断提供客观依据。 |
关键词: 肝脏局灶性病变 灰阶超声影像组学 超声造影 诊断价值Diagnostic value of gray-scale sonography and contrast-enhanced ultrasound in focal liver lesions |
DOI: |
投稿时间:2022-06-06修订日期:2022-06-29 |
基金项目: |
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Comparison on the diagnostic value of gray-scale ultrasonography radiomics and contrast-enhanced ultrasonography in patients with focal liver lesions |
wangxinran |
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Abstract: |
Objective To compare the diagnostic value of gray-scale ultrasound and contrast-enhanced ultrasound radiomic features in patients with focal liver lesions (FLLs). Methods The clinical data of 162 patients with FLLs who underwent gray-scale ultrasound or contrast-enhanced ultrasound examinations in the hospital from February 2017 to November 2021 were retrospectively analyzed. The diagnostic value of the two methods for FLLs was compared. Results Contrast-enhanced ultrasound found that the intensity of malignant lesions in hepatic arterial phase was higher than that of surrounding tissues, and the enhancement in portal venous phase was stronger than that of surrounding liver tissues, with a clear boundary between the two. Contrast-enhanced ultrasound found that compared with surrounding liver tissues, benign lesions showed iso-enhancement or slightly high enhancement in hepatic arterial phase, and contrast agent moved slowly from the periphery to the center of lesion. The benign lesions showed iso-enhancement or high enhancement in portal venous phase and delayed phase, without obvious regression of contrast agent. 1 histogram characteristic, 1 texture characteristic and 3 wavelet characteristics were taken as the predictive factors the 274 radiomic features. The area under the curve (AUC), sensitivity and specificity of training cohort and validation cohort the 274 radiomic features to predict malignant lesions were 0.872, 83.33%, 80.00% and 0.812, 76.67%, 79.24%, without statistically significant difference (P>0.05). The AUC, sensitivity and specificity of radiomic model were significantly higher than those of contrast-enhanced ultrasound (P<0.05). Conclusion The gray-scale ultrasound radiomic features are effective in the diagnosis of benign and malignant FLLs, and can achieve better performance than contrast-enhanced ultrasound, which provides an objective basis for clinical diagnosis. |
Key words: Focal liver lesion Gray-scale ultrasound radiomics Contrast-enhanced ultrasound Diagnostic value |