摘要: |
声动力疗法(sonodynamic treatment,SDT)是一种由光动力(photodynamic treatment ,PDT)发展而来的新兴的无创的治疗方法,由于具有更深的辐射距离和不具有光毒性特点逐渐替代传统的PDT。氧气是SDT发挥抗肿瘤过程重要的一环,但是肿瘤长期处于缺氧微环境中,极大限制SDT的疗效。纳米材料可灵活应对肿瘤微环境这一缺氧特点,提供有效的供氧策略增强SDT抗肿瘤效应。当前对于纳米材料通过改善缺氧来增强SDT抗肿瘤疗效这方面的综述较少,因此本文简单介绍SDT的作用机制, 主要讨论纳米材料改善肿瘤缺氧从而增强SDT的研究进展。 |
关键词: 声动力治疗 缺氧 纳米 肿瘤 |
DOI: |
投稿时间:2020-05-08修订日期:2020-05-17 |
基金项目:国家自然科学(81974267);湖南省卫生健康委科研(B2019166) |
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Research Progress of Nanomaterials to Enhance the Efficacy of SDT by Relieving Tumor Hypoxia |
Biying Huang,Chengcheng Niu |
(Department of Ultrasound Diagnosis,Second Xiangya Hospital,Central South University) |
Abstract: |
Sonodynamic treatment (SDT) is a new non-invasive treatment method developed from photodynamic treatment (PDT). Due to the deeper radiation distance and no phototoxicity characteristics, it gradually replaces traditional PDT. Oxygen is an important part of the SDT in anti-tumor process, but the tumor has been in a hypoxic microenvironment for a long time, which greatly limits the efficacy of SDT. Nanomaterials can flexibly respond to the hypoxic characteristics of the tumor microenvironment and provide effective oxygen supply strategies to enhance the anti-tumor effect of SDT. At present, there are few reviews on nanomaterials to improve the antitumor efficacy of SDT by improving hypoxia, so this review briefly introduces the mechanism of SDT, mainly discusses the progress of nanomaterials in improving tumor hypoxia and enhancing the sonodynamic efficacy. |
Key words: Sonodynamic therapy (SDT) Hypoxia Nanomaterials Cancer |