摘要: |
目的 建立符合上海地区人群特征的早孕期胚胎/胎儿心率(embryonic/fetal heart rate, EHR)变化规律及参考值范围。方法 收集早孕期胎儿的胎心率、孕妇及胚胎的临床病史、实验室检查等相关临床资料。采用腔内和(或)经腹部超声测量胎儿胚芽/头臀长,观测胎心搏动,M型超声或脉冲多普勒(pulse wave,PW)测量胎心率。结果 1、胚芽/头臀长(Crown-rump length, CRL)为2-3mm或孕龄(Gestational age, GA)40-41天(day)时胎心率为117.31±11.64次/分(beats per minute, bpm),胎心率随着GA或CRL逐渐增加而上升,并在GA63-69天或CRL23~30mm时胎心率达到峰值172.69±9.27( bpm),随后EHR随着GA或CRL的增长缓慢下降趋于稳定。2、基于各时期胎心率变化规律建立回归方程:EHR(bpm)=-223.751+11.746GA(day)-0.086GA^2 (day)(R^2=0.772,R=0.877,P<0.0001);EHR(bpm)=101.83+5.108CRL(mm)-0.084CRL^2 (mm)(R^2=0.765,R=0.875,P<0.0001)。结论 以孕龄及胎芽/头臀长为基准, 上海地区人群早孕期第5、第50及第95百分位胎心率参考值范围被建立,为临床预测胎儿妊娠结局提供参考依据。 |
关键词: 超声 孕早期 胎心率 妊娠结局 |
DOI: |
投稿时间:2019-01-07修订日期:2020-01-13 |
基金项目: |
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The investigation of embryonic/fetal heart ratechange pattern in first trimester |
WangGuanjie,Cao Yunyun |
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Abstract: |
Objective: To investigate and establish the reference range of embryonic/fetal heart rate(EHR) during early pregnancy that in accordance with the characteristics of Shanghai population. Methods: The EHR, the clinical history and laboratory examination of pregnant women and embryos were collected. Embryonic / Crown-rump length(CRL) and the heartbeat was detected by transvaginal and/or transabdominal ultrasound. Embryonic/fetal heart beat was measured by M type ultrasound or pulse Doppler (pulse wave, PW). Results: 1. When CRL was 2-3mm or gestational age (GA) was 40-41 days, the fetal heart rate was 117.31 + 11.64 beat/min (beats per minute, bpm). Then EHR raised with the increase of GA/CRL, and at the 63-69 day of the gestational age when the embryo length was 23~30mm, the heart rate reached thr peak of 172.69 ±9.27 bpm. After that, the EHR gradually decreased and tend to stable with the GA or CRL. 2. The regression equation was established through the changes of EHR in each period: EHR(bpm)=-223.751+11.746GA(day)-0.086GA^2 (day)(R^2=0.772,R=0.877,P<0.0001);EHR(bpm)=101.83+5.108CRL(mm)-0.084CRL^2 (mm)(R^2=0.765,R=0.875,P<0.0001). Conclusion: Based on the gestational age and length of GA/CRL, the regression equation was established, and the 5th, 50th and 95th percentile of HER in Shanghai area, which was helpful to clinical diagnosis and treatment. |
Key words: Sonography first trimester embryonic/fetal heart rate Pregnancy outcomes |